General
Preferred name
AZD-4017
Synonyms
CHEMBL2153191 ()
AZD 4017 ()
AZD4017 ()
P&D ID
PD046646
CAS
1024033-43-9
Tags
available
probe
drug candidate
Drug indication
Ocular hypertension
Obesity
Drug Status
investigational
Max Phase
2.0
Probe info
Probe type
calculated probe
experimental probe
P&D approved
Probe selectivity
protein-selective
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
3
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
AZD 4017 is a potent, selective 11¦Â-Hydroxysteroid Dehydrogenase Type 1 (11¦Â-HSD1) inhibitor, with an IC50 of 7 nM.
PRICE
248
DESCRIPTION
AZD 4017 is an inhibitor of 11??-Hydroxysteroid Dehydrogenase Type 1(11??-HSD1) (IC50: 7 nM).
DESCRIPTION
AZD4017 is a selective inhibitor of 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) . This compound is listed in AstraZeneca's OpenInnovation Pharmacology Toolbox .
(GtoPdb)
MOA
Inhibitor
(Chemical Probes.org)
DESCRIPTION
AZD4017 is a potent, selective, and orally bioavailable 11β-HSD1 inhibitor (11β-hydroxysteroid dehydrogenase type 1 inhibitor). Inhibition of 11β-HSD1 is an attractive mechanism for the treatment of obesity and other elements of the metabolic syndrome.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
AZD 4017 is an inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) (IC50: 7 nM).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Chemical Probes.org
DrugBank
DrugMAP
Guide to Pharmacology
High-quality chemical probes
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
Tool Compound Set
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
25
Molecular Weight
419.22
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
3
Aromatic Ring Count
1
cLogP
4.34
TPSA
82.53
Fraction CSP3
0.68
Chiral centers
1.0
Largest ring
6.0
QED
0.61
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
11-beta-hydroxysteroid dehydrogenase 1
11β-HSD1
11β-HSD
HSD11B1
11¦Â-HSD
Pathway
Metabolic Enzyme/Protease
Metabolism
Target class
Enzyme
Target subclass
Dehydrogenase
Source data
